Here are few things right out of cisco documentation to keep in mind when deploying vPC's. I couldn't find all this at one place in the Cisco documentation (maybe I didn't look hard enough:) so I decided to put it here for those needing a quick fact check:
1. vPC peer link MUST consist of 10G ports.
2. vPC domains can't be stretched across multiple VDCs on the same switch.
3. vPC can't contain links that are terminated on different VDCs on the same switch.
4. You can only have ONE vPC domain per VDC or switch.
5. vPC domain can't have more than two peer switches or VDCs.
6. VDC configured for vPC must have its own vPC keepalive link and vPC peer link.
7. Since vPC is a layer 2 port channel, vPC doesn't support L3 port channels.
1. vPC peer link MUST consist of 10G ports.
2. vPC domains can't be stretched across multiple VDCs on the same switch.
3. vPC can't contain links that are terminated on different VDCs on the same switch.
4. You can only have ONE vPC domain per VDC or switch.
5. vPC domain can't have more than two peer switches or VDCs.
6. VDC configured for vPC must have its own vPC keepalive link and vPC peer link.
7. Since vPC is a layer 2 port channel, vPC doesn't support L3 port channels.
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